RECOMBINANT GLOBULINS - NOVEL RESEARCH TOOLS AND POSSIBLE PHARMACEUTICALS

被引：16
作者：
HOLLENBAUGH, D
CHALUPNY, NJ
ARUFFO, A
机构：
[1] Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, WA
来源：
CURRENT OPINION IN IMMUNOLOGY | 1992年 / 4卷 / 02期
关键词：
D O I：
10.1016/0952-7915(92)90017-9
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A novel approach to the study of proteins is the construction of chimeras consisting of a target protein fused to an immunoglobulin constant domain. These recombinant globulins have been used in the identification of ligand-receptor pairs, determination of functional consequences of receptor engagement, the elucidation of structural domains necessary for ligand binding, and as potential therapeutic agents.
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页码：216 / 219
页数：4
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