ANGIOGENESIS IN CANCER, VASCULAR, RHEUMATOID AND OTHER DISEASE

被引：6749
作者：
FOLKMAN, J [1 ]
机构：
[1] HARVARD UNIV,SCH MED,BOSTON,MA 02115
来源：
NATURE MEDICINE | 1995年 / 1卷 / 01期
关键词：
D O I：
10.1038/nm0195-27
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent discoveries of endogenous negative regulators of angiogenesis, thrombospondin, angiostatin and glioma-derived angiogenesis inhibitory factor, all associated with neovascularized tumours, suggest a new paradigm of tumorigenesis. It is now helpful to think of the switch to the angiogenic phenotype as a net balance of positive and negative regulators of blood vessel growth. The extent to which the negative regulators are decreased during this switch may dictate whether a primary tumour grows rapidly or slowly and whether metastases grow at all.
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页码：27 / 31
页数：5
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