SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF DIHYDROFUROBENZOXAZOLIN-2(3H)-ONES AND THEIR DERIVATIVES

A series of dihydrofurobenzoxalin-2 (3H)-ones and their derivatives were synthesized. The structures of the compounds have been elucidated by IR, mass, H-1-NMR spectra and elementary analysis. The in invitro activity of these compounds was investigated against Gram-positive and Gram-negative bacteria and also against Candida albicans. 7,7-Dimethyl-7,8-dihydro-furo[2,3-g]benzoxazolin-2 (3H)-one (compound 2) proved to be more potent than compound 1. Compound 3 also showed significant activity against all the microbes tested. Compounds 4 and 5 were more effective against Gram-positive bacteria than Gram-negative bacteria but inactive against C. albicans.