Cutaneous Langerhans cell histiocytosis: Report of two cases

被引:1
作者
Utsav, Sharma [1 ]
Geng, Songmei [1 ]
机构
[1] Xi An Jiao Tong Univ, Affiliated Hosp Xian 2, Dept Dermatol, Xian, Shaanxi, Peoples R China
来源
AMERICAN JOURNAL OF CASE REPORTS | 2011年 / 12卷
关键词
cutaneous; Langerhans cell histiocytosis;
D O I
10.12659/AJCR.882097
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Langerhans cell histiocytosis (LCH) is a rare proliferative disorder of Langerhans cells, with a broad spectrum of clinical manifestation and prognosis. Here, we present 2 cases of cutaneous LCH in young children with good prognosis. Case Report: A 6-month-old girl showed generalized multiple reddish-brown papules with crust over the trunk. The second patient was a boy aged 2.5 years who also presented with generalized papules with crust and ulcers over the trunk and was treated for eczema and psoriasis with no improvement. In both cases, routine laboratory and radiological examinations were normal, and skin biopsies revealed atrophic epidermis and a dense infiltration of large histiocytic cells with eosinophilic cytoplasm and reniform nuclei. The histiocytes were positive for S100 and CD1a, thus confirming the diagnosis of LCH. Both patients were prescribed chemotherapy including prednisone, vincristine, and azathioprine for 6 months. Conclusions: Through this case report, we wish to emphasize the importance of both histopathological and immunohistochemical confirmation for the diagnosis of cutaneous manifestations of LCH, as well as recommending a long-term follow-up to monitor recovery and evidence of relapse.
引用
收藏
页码:154 / 158
页数:5
相关论文
共 30 条
  • [1] Epidermotropic lesions: a review
    Abbas, Ossama
    Bhawan, Jag
    [J]. JOURNAL OF CUTANEOUS PATHOLOGY, 2009, 36 (10) : 1037 - 1052
  • [2] Langerhans cell histiocytosis: Current concepts and treatments
    Abla, Oussama
    Egeler, R. Maarten
    Weitzman, Sheila
    [J]. CANCER TREATMENT REVIEWS, 2010, 36 (04) : 354 - 359
  • [3] Sarcoptes scabiei infestation misdiagnosed and treated as Langerhans cell histiocytosis
    Burch, JM
    Krol, A
    Weston, WL
    [J]. PEDIATRIC DERMATOLOGY, 2004, 21 (01) : 58 - 62
  • [4] Langerhans cell histiocytosis: malignancy or inflammatory disorder doing a great job of imitating one?
    Degar, Barbara A.
    Rollins, Barrett J.
    [J]. DISEASE MODELS & MECHANISMS, 2009, 2 (9-10) : 436 - 439
  • [5] FAVARA BE, 1987, LANCET, V1, P208
  • [6] Fung YP, 2001, HONG KONG DERMATOLOG, V9, P66
  • [7] Hansen R C, 1991, Adv Dermatol, V6, P161
  • [8] Howarth DM, 1999, CANCER-AM CANCER SOC, V85, P2278, DOI 10.1002/(SICI)1097-0142(19990515)85:10<2278::AID-CNCR25>3.0.CO
  • [9] 2-U
  • [10] LANGERHANS CELL HISTIOCYTOSIS WITH GASTROINTESTINAL INVOLVEMENT
    JAFFE, R
    WOLLMAN, MR
    KOCOSHIS, S
    PENCHANSKY, L
    GILBERTBARNESS, E
    [J]. AMERICAN JOURNAL OF DISEASES OF CHILDREN, 1993, 147 (01): : 79 - 80