CENTRAL EFFECTS OF 5-HT ON RESPIRATORY AND HYPOGLOSSAL ACTIVITIES IN THE ADULT CAT

被引：41

作者：

ROSE, D

KHATERBOIDIN, J

TOUSSAINT, P

DURON, B

机构：

[1] Laboratoire de Neurophysiologie Clinique et Expérimentale, Ontogenèse des Systèmes Moteurs Intégrés, URA 1331 CNRS, 80036 Amiens

来源：

RESPIRATION PHYSIOLOGY | 1995年 / 101卷 / 01期

关键词：

MAMMALS; (CAT); MEDIATORS; (S-HT); MUSCLES; (RESPIRATORY); PHARMACOLOGICAL AGENTS; (8-OH-DPAT DOI); RECEPTORS; (CENTRAL SEROTONIN);

D O I：

10.1016/0034-5687(95)00008-2

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The activities of the diaphragmatic, internal intercostal and hypoglossal-innervated muscles were studied in adult decerebrate cats in response to 5-HT and related agents (8-OH-DPAT and DOI). The drugs were placed on the floor of the IVth ventricle. The mean respiratory frequency (Fi) increased (124-193% of the control value) within 3 min of the 5-HT application, and decreased thereafter (30-90%). The mean Ti and Te changed similarly, but opposite to Fi. With some delay, the hypoglossal-innervated muscles were tonically activated or exhibited increased activities. Methysergide pretreatment completely blocked the effect of 5-HT on all the respiratory parameters and the hypoglossal-innervated muscles activities. The responses to and OH-DPAT and DOI indicate that 5-HT modulates the respiratory frequency via activation of both 5-RT(1A) and 5-HT2 receptors. Nevertheless, the effect of 5-HT on both the expiratory and hypoglossal-innervated muscles seems to depend on 5-HT2, receptors activation only.

引用

页码：59 / 69

页数：11

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