DNA-REPAIR ENZYMES

被引：9

作者：

MORIKAWA, K ^{[1
]}

机构：

[1] PROT ENGN RES INST,OSAKA,JAPAN

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1993年 / 3卷 / 01期

关键词：

D O I：

10.1016/0959-440X(93)90196-R

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Combined with site-directed mutagenesis, X-ray structural determination at atomic resolution allows the identification of a catalytic center and other functionally important regions in the three-dimensional structures of proteins that are involved in the excision repair of modified bases within DNA or in recombinational repair. Recent biochemical and genetic approaches, including recombinant DNA techniques, have also provided new insights into-the molecular mechanisms of DNA repair in terms of the tertiary structures of proteins and DNA.

引用

页码：17 / 23

页数：7

共 34 条

[1] SUBSTRATE-SPECIFICITY OF THE ESCHERICHIA-COLI FPG PROTEIN (FORMAMIDOPYRIMIDINE DNA GLYCOSYLASE) - EXCISION OF PURINE LESIONS IN DNA PRODUCED BY IONIZING-RADIATION OR PHOTOSENSITIZATION [J].