PLATELET-ACTIVATING-FACTOR (PAF) INDUCES CONTRACTION OF SAPONIN-SKINNED SMOOTH-MUSCLE OF CORONARY-ARTERY

被引：4

作者：

SOLOVIEV, AI ^{[1
]}

BRAQUET, P ^{[1
]}

机构：

[1] H BEAUFOUR INST,F-92350 LE PLESSIS ROBINS,FRANCE

来源：

LIPIDS | 1991年 / 26卷 / 12期

关键词：

D O I：

10.1007/BF02536546

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of platelet-activating factor (PAF) on the development of isometric tension by saponin-skinned coronary artery was studied. PAF caused two types of contractions of coronary smooth muscle cells (SMC): (i) rapid, transient (phasic) contractions of SMC were induced by inositol 1,4,5-trisphosphate dependent Ca2+ release from sarcoplasmic reticulum (SR); (ii) slow sustained (tonic) contractions were induced by increase in Ca2+-sensitivity of the contractile apparatus of SMC by protein kinase C activation. The present results support the hypothesis that, in SMC of coronary artery, PAF receptors are located not only on the plasma membrane, but also on the SR membranes.

引用

页码：1274 / 1276

页数：3

共 8 条

[1] THE EFFECTS OF PAF-ACETHER ON THE CARDIOVASCULAR-SYSTEM AND THEIR INHIBITION BY A NEW HIGHLY SPECIFIC PAF-ACETHER RECEPTOR ANTAGONIST BN 52021 [J].