POTENTIATION OF A BEHAVIORAL-RESPONSE IN MICE BY SPINAL COADMINISTRATION OF SUBSTANCE-P AND EXCITATORY AMINO-ACID AGONISTS

被引:56
作者
MJELLEMJOLY, N [1 ]
LUND, A [1 ]
BERGE, OG [1 ]
HOLE, K [1 ]
机构
[1] ASTRA PAIN CONTROL,SODERTALJE,SWEDEN
关键词
EXCITATORY AMINO ACID; SUBSTANCE-P; INTRATHECAL INJECTION; NOCICEPTION; MOUSE;
D O I
10.1016/0304-3940(91)90072-2
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The functional interaction in the spinal cord between substance P and excitatory amino acid agonists was investigated. Behavioural responses were scored in mice after intrathecal administration of excitatory amino acid agonists and substance P, given separately or in combination. A strong potentiation of the effect was seen when substance P was coadministered with N-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) or kainic acid (KA). The potentiation was blocked by the corresponding antagonists: the selective NMDA-receptor antagonist (+/-)-3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP), the non-NMDA receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and the substance P analog, [D-Arg1,D-Trp7,9,Leu11]-substance P (Spantide). These findings indicate a functional interaction between substance P and glutamate in the dorsal horn of the spinal cord, compatible with the hypothesis that corelease of substance P and glutamate from primary afferent neurons may enhance nociception.
引用
收藏
页码:121 / 124
页数:4
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