The importance of AgNOR method in the prognosis and comparison with some clinic parameters in gestational trophoblastic disease

To investigate AgNOR method which is an cell proliferation marker is studied as AgNORcan be a parameter of defining gestational trophoblastic disease persistancy by studying the correlation between beta-hCG and AgNOR levels. In this study, as control group; 14 term plasenta, 14 spountaneus abortus and as GTD group; 15 partial hydatiform mole, 18 comlete hydatiform mole and 15 persistant hydatiform mole cases are included which were diagnosed between 1997-2003 in our clinic. The AgNOR method is applied to all patients. The evaluation of materials are done on light microscope. Counting systems proposed for AgNOR by crocker were used. In the study, the highest level of AgNOR avarage were detected in persistant mole group. The least average were detected in the placenta group. The AgNOR avarages of the GTD cases were higher than the AgNOR avarages of the control cases (p<0.05). The AgNOR avarages of the persistant mole cases were found higher than complete mole cases (p<0.05). But no diference were detected between the AgNOR avarages of the complete and partial mole cases (p>0.05). We couldnt detect any corralation between the serum beta-hCG levels and the AgNOR avarages, on the other hand if the AgNOR avarages were increasing, the period to decrease normal levels of beta-hCG levels was found to be prolonged. The defining of AgNOR method in ability and persistancy of gestational trophoblastic disease is more economic and easier than beta-hCG levels which is an important parameters gestational trophoblastic disease.