THIAMINE-REPRESSIBLE GENES IN SCHIZOSACCHAROMYCES-POMBE ARE REGULATED BY A CYS(6) ZINC-FINGER MOTIF-CONTAINING PROTEIN

被引：18

作者：

FANKHAUSER, H ^{[1
]}

SCHWEINGRUBER, ME ^{[1
]}

机构：

[1] UNIV BERN, INST GEN MICROBIOL, CH-3012 BERN, SWITZERLAND

来源：

GENE | 1994年 / 147卷 / 01期

关键词：

YEAST; TRANSCRIPTION FACTOR; GENE REGULATION;

D O I：

10.1016/0378-1119(94)90054-X

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Our previous genetic data indicate that the product of the Schizosaccharomyces pombe thi1 gene acts as an activator of several thiamine-repressible genes which are involved in the control of thiamine metabolism [Schweingruber et al., Genetics 130 (1992) 445-449; Zurlinden and Schweingruber, Gene 117 (1992) 141-143]. In this communication, we report the cloning and sequencing of thi1 and show that it carries an open reading frame which translates into a 775-amino-acid protein with the characteristics of a Cys(6) zinc-finger-motif-containing transcription factor, as typified by Saccharomyces cerevisae GAL4. We, therefore, suggest that the thi1-encoded protein binds to upstream activator sequences of thiamine-repressible genes.

引用

页码：141 / 144

页数：4

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