CALCIUM REGULATION OF GENE-EXPRESSION IN NEURONAL CELLS

被引:275
作者
GHOSH, A [1 ]
GINTY, DD [1 ]
BADING, H [1 ]
GREENBERG, ME [1 ]
机构
[1] HARVARD UNIV, SCH MED, DEPT MICROBIOL & MOLEC GENET, BOSTON, MA 02115 USA
来源
JOURNAL OF NEUROBIOLOGY | 1994年 / 25卷 / 03期
关键词
CALCIUM SIGNALING; GENE EXPRESSION; NEURONAL PLASTICITY;
D O I
10.1002/neu.480250309
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Long-term adaptive changes in neurons following brief periods of neuronal activity are likely to involve changes in gene expression. The mechanisms of activity-dependent gene expression have been explored in central neurons and the neuronal cell line PC12. Calcium influx through either NMDA receptors or voltage-sensitive calcium channels leads to the rapid induction of a number of immediate-early genes including c-fos. Promoter analysis indicates that Ca2+ influx through different calcium channels activates distinct signaling pathways that either target the serum response element (SRE) or the calcium response element (CaRE) within the c-fos promoter. Transcription through the CaRE requires the induced phosphorylation of the cAMP response element binding protein (CREB) at Ser133. This site on CREB is also phosphorylated in the suprachiasmatic nucleus in vivo upon light stimulation. These observations suggest Ca2+ can regulate gene expression by multiple signaling pathways including one that involves the Ca2+-dependent phosphorylation of the transcription factor CREB. (C) 1994 John Wiley and Sons, Inc.
引用
收藏
页码:294 / 303
页数:10
相关论文
共 39 条
[1]   LONG-TERM POTENTIATION AND NMDA RECEPTORS IN RAT VISUAL-CORTEX [J].
ARTOLA, A ;
SINGER, W .
NATURE, 1987, 330 (6149) :649-652
[2]  
ASCHER P, 1988, J PHYSIOL-LONDON, V399, P247
[3]   REGULATION OF GENE-EXPRESSION IN HIPPOCAMPAL-NEURONS BY DISTINCT CALCIUM SIGNALING PATHWAYS [J].
BADING, H ;
GINTY, DD ;
GREENBERG, ME .
SCIENCE, 1993, 260 (5105) :181-186
[4]   STIMULATION OF PROTEIN TYROSINE PHOSPHORYLATION BY NMDA RECEPTOR ACTIVATION [J].
BADING, H ;
GREENBERG, ME .
SCIENCE, 1991, 253 (5022) :912-914
[5]   ASSOCIATIVE LONG-TERM POTENTIATION IN HIPPOCAMPAL SLICES [J].
BARRIONUEVO, G ;
BROWN, TH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (23) :7347-7351
[6]   MULTIPLE SEQUENCE ELEMENTS OF A SINGLE FUNCTIONAL CLASS ARE REQUIRED FOR CYCLIC-AMP RESPONSIVENESS OF THE MOUSE C-FOS PROMOTER [J].
BERKOWITZ, LA ;
RIABOWOL, KT ;
GILMAN, MZ .
MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (10) :4272-4281
[7]   LONG-LASTING POTENTIATION OF SYNAPTIC TRANSMISSION IN DENTATE AREA OF ANESTHETIZED RABBIT FOLLOWING STIMULATION OF PERFORANT PATH [J].
BLISS, TVP ;
LOMO, T .
JOURNAL OF PHYSIOLOGY-LONDON, 1973, 232 (02) :331-356
[8]   ACTIVITY-DEPENDENT DECREASE IN NMDA RECEPTOR RESPONSES DURING DEVELOPMENT OF THE VISUAL-CORTEX [J].
CARMIGNOTO, G ;
VICINI, S .
SCIENCE, 1992, 258 (5084) :1007-1011
[9]   RAPID INCREASE OF AN IMMEDIATE EARLY GENE MESSENGER-RNA IN HIPPOCAMPAL-NEURONS BY SYNAPTIC NMDA RECEPTOR ACTIVATION [J].
COLE, AJ ;
SAFFEN, DW ;
BARABAN, JM ;
WORLEY, PF .
NATURE, 1989, 340 (6233) :474-476
[10]   NMDA RECEPTORS - THEIR ROLE IN LONG-TERM POTENTIATION [J].
COLLINGRIDGE, GL ;
BLISS, TVP .
TRENDS IN NEUROSCIENCES, 1987, 10 (07) :288-293