REGULATION OF INSULIN-SECRETION - THE ROLE OF 2ND-MESSENGERS

被引：37
作者：
HOWELL, SL
JONES, PM
PERSAUD, SJ
机构：
[1] Biomedical Sciences Division, King's College London, London, W8 7AH, Campden Hill Road
来源：
DIABETOLOGIA | 1994年 / 37卷
基金：
英国惠康基金;
关键词：
ISLETS OF LANGERHANS; INSULIN SECRETION; PROTEIN KINASE A; CYCLIC AMP; CALCIUM-CALMODULIN; PROTEIN KINASE C; ARACHIDONIC ACID; NITRIC OXIDE;
D O I：
10.1007/BF00400823
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
This review summarises briefly studies performed in the last 5-6 years concerning the role of second messengers in the regulation of insulin secretion, using intact and electrically permeabilized rat islets of Langerhans. It is concluded that cyclic AMP (through protein kinase A), calcium (through calcium-calmodulin dependent protein kinases) and diacylglyceror (through protein kinase C) may be important second messengers in modulating the effects of specific secretagogues on insulin release. However, recent studies strongly suggest that neither protein kinase A nor protein kinase C are directly involved in the regulation of insulin secretion by glucose. The possible involvement of other second messengers, nitric oxide and arachidonic acid, in the regulation of secretion is also briefly reviewed.
引用
收藏
页码：S30 / S35
页数：6
相关论文
共 36 条
[21]   ARACHIDONIC-ACID AND ITS METABOLITES - EVOLVING ROLES AS TRANSMEMBRANE SIGNALS FOR INSULIN RELEASE [J].
METZ, SA .
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 1988, 32 (03) :187-202
[22]   MODE OF ACTION OF ADENOSINE 3'-5'-CYCLIC MONOPHOSPHATE IN MAMMALIAN ISLETS OF LANGERHANS - EFFECTS OF INSULIN SECRETAGOGUES ON ISLET-CELL PROTEIN KINASE-ACTIVITY [J].
MONTAGUE, W ;
HOWELL, SL .
BIOCHEMICAL JOURNAL, 1973, 134 (01) :321-327
[23]   INHIBITION OF INSULIN RELEASE BY STAUROSPORINE AND RO-31-8220 - A ROLE FOR PROTEIN-KINASE-C [J].
PERSAUD, SJ ;
JONES, PM .
BIOCHEMICAL SOCIETY TRANSACTIONS, 1994, 22 (02) :S208-S208
[24]   STAUROSPORINE INHIBITS PROTEIN-KINASES ACTIVATED BY CA2+ AND CYCLIC-AMP IN ADDITION TO INHIBITING PROTEIN-KINASE-C IN RAT ISLETS OF LANGERHANS [J].
PERSAUD, SJ ;
JONES, PM ;
HOWELL, SL .
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1993, 94 (01) :55-60
[25]   ACTIVATION OF PROTEIN-KINASE-C PARTIALLY ALLEVIATES NORADRENALINE INHIBITION OF INSULIN-SECRETION [J].
PERSAUD, SJ ;
JONES, PM ;
HOWELL, SL .
BIOCHEMICAL JOURNAL, 1993, 289 :497-501
[26]   GLUCOSE-STIMULATED INSULIN-SECRETION IS NOT DEPENDENT ON ACTIVATION OF PROTEIN KINASE-A [J].
PERSAUD, SJ ;
JONES, PM ;
HOWELL, SL .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 173 (03) :833-839
[27]   ACTIVATION OF PROTEIN-KINASE-C IS ESSENTIAL FOR SUSTAINED INSULIN-SECRETION IN RESPONSE TO CHOLINERGIC STIMULATION [J].
PERSAUD, SJ ;
JONES, PM ;
HOWELL, SL .
BIOCHIMICA ET BIOPHYSICA ACTA, 1991, 1091 (01) :120-122
[28]  
PERSAUD SJ, 1993, PHARM COMMUN, V3, P39
[29]   GLUCOSE AND CARBACHOL GENERATE 1,2-DIACYLGLYCEROLS BY DIFFERENT MECHANISMS IN PANCREATIC-ISLETS [J].
PETERRIESCH, B ;
FATHI, M ;
SCHLEGEL, W ;
WOLLHEIM, CB .
JOURNAL OF CLINICAL INVESTIGATION, 1988, 81 (04) :1154-1161
[30]   CA-2+, CAMP, AND PHOSPHOLIPID-DERIVED MESSENGERS IN COUPLING MECHANISMS OF INSULIN-SECRETION [J].
PRENTKI, M ;
MATSCHINSKY, FM .
PHYSIOLOGICAL REVIEWS, 1987, 67 (04) :1185-1248
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