REGULATION OF INSULIN-SECRETION - THE ROLE OF 2ND-MESSENGERS

被引：37

作者：

HOWELL, SL

JONES, PM

PERSAUD, SJ

机构：

[1] Biomedical Sciences Division, King's College London, London, W8 7AH, Campden Hill Road

来源：

DIABETOLOGIA | 1994年 / 37卷

基金：

英国惠康基金;

关键词：

ISLETS OF LANGERHANS; INSULIN SECRETION; PROTEIN KINASE A; CYCLIC AMP; CALCIUM-CALMODULIN; PROTEIN KINASE C; ARACHIDONIC ACID; NITRIC OXIDE;

D O I：

10.1007/BF00400823

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This review summarises briefly studies performed in the last 5-6 years concerning the role of second messengers in the regulation of insulin secretion, using intact and electrically permeabilized rat islets of Langerhans. It is concluded that cyclic AMP (through protein kinase A), calcium (through calcium-calmodulin dependent protein kinases) and diacylglyceror (through protein kinase C) may be important second messengers in modulating the effects of specific secretagogues on insulin release. However, recent studies strongly suggest that neither protein kinase A nor protein kinase C are directly involved in the regulation of insulin secretion by glucose. The possible involvement of other second messengers, nitric oxide and arachidonic acid, in the regulation of secretion is also briefly reviewed.

引用

页码：S30 / S35

页数：6

共 36 条

[1] GLUCOSE-INDUCED CHANGES IN CYTOPLASMIC FREE CA-2+ CONCENTRATION AND THE SIGNIFICANCE FOR THE REGULATION OF INSULIN RELEASE - MEASUREMENTS WITH FURA-2 IN SUSPENSIONS AND SINGLE AGGREGATES OF MOUSE PANCREATIC BETA-CELLS [J].