LIVER-ENZYME INDUCTION AND SERUM-LIPID LEVELS AFTER REPLACEMENT OF CARBAMAZEPINE WITH OXCARBAZEPINE

被引：78
作者：
ISOJARVI, JIT
PAKARINEN, AJ
RAUTIO, A
PELKONEN, O
MYLLYLA, VV
机构：
[1] UNIV OULU,DEPT CLIN CHEM,SF-90220 OULU,FINLAND
[2] UNIV OULU,DEPT PHARMACOL & TOXICOL,SF-90220 OULU,FINLAND
来源：
EPILEPSIA | 1994年 / 35卷 / 06期
关键词：
EPILEPSY; CARBAMAZEPINE; OXCARBAZEPINE; LIVER ENZYME INDUCTION; LIPIDS;
D O I：
10.1111/j.1528-1157.1994.tb01792.x
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
We evaluated liver P450 enzyme system induction and serum lipid levels in a prospective follow-up study in 12 male patients with epilepsy after replacing carbamazepine (CBZ) medication with oxcarbazepine (OCBZ). Antipyrine(t1/2) increased and antipyrine(CL) decreased 2 months after the medication was changed, reflecting normalization of liver P450 enzyme system function. Furthermore, serum total cholesterol levels decreased, but serum concentrations of high-density lipoprotein (HDL)-cholesterol and triglycerides (TG) were unchanged. OCBZ may be the preferable antiepileptic drug (AED) with regard to the effects of the medication on lipid metabolism.
引用
收藏
页码：1217 / 1220
页数：4
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