EUPENIFELDIN, A NOVEL CYTOTOXIC BISTROPOLONE FROM EUPENICILLIUM-BREFELDIANUM

被引：57
作者：
MAYERL, F
GAO, Q
HUANG, S
KLOHR, SE
MATSON, JA
GUSTAVSON, DR
PIRNIK, DM
BERRY, RL
FAIRCHILD, C
ROSE, WC
机构：
[1] Pharmaceutical Research Institute, Wallingford, Connecticut 06492, Bristol-Myers Squibb Company
来源：
JOURNAL OF ANTIBIOTICS | 1993年 / 46卷 / 07期
关键词：
D O I：
10.7164/antibiotics.46.1082
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Eupenifeldin was isolated from cultures of Eupenicillium brefeldianum ATCC 74184 by extraction and crystallization. The compound was identified as a pentacyclic bistropolone on the basis of spectral data and its complete structure was established by single-crystal X-ray analysis. The compound is cytotoxic against the HCT-1 16 cell line and has in vivo antitumor activity in the P388 leukemia model.
引用
收藏
页码：1082 / 1088
页数：7
相关论文
共 11 条
  • [1] STRUCTURE OF FUSARIOCIN-C, A CYTO-TOXIC METABOLITE FROM FUSARIUM-MONILIFORME
    ITO, T
    ARAI, T
    OHASHI, Y
    SASADA, Y
    [J]. AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1981, 45 (07): : 1689 - 1692
  • [2] ITO T, 1979, AGR BIOL CHEM TOKYO, V43, P1237
  • [3] SYNOPTIC KEY TO GENUS EUPENICILLIUM AND TO SCLEROTIGENIC PENICILLIUM SPECIES
    PITT, JI
    [J]. CANADIAN JOURNAL OF BOTANY-REVUE CANADIENNE DE BOTANIQUE, 1974, 52 (11): : 2231 - 2236
  • [4] QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS OF COLCHICINES AGAINST P388 LEUKEMIA IN MICE
    QUINN, FR
    BEISLER, JA
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1981, 24 (03) : 251 - 256
  • [5] SCOTT D, 1968, CSIR272 RES REP
  • [6] SCUDIERO DA, 1988, CANCER RES, V48, P4827
  • [7] C-13 NUCLEAR MAGNETIC-RESONANCE SPECTRUM OF COLCHICINE
    SINGH, SP
    PARMAR, SS
    STENBERG, VI
    FARNUM, SA
    [J]. SPECTROSCOPY LETTERS, 1977, 10 (12) : 1001 - 1012
  • [8] STOLK AC, 1967, PERSOONIA, V4, P391
  • [9] BMY-28438 (3,7-DIHYDROXYTROPOLONE), A NEW ANTITUMOR ANTIBIOTIC ACTIVE AGAINST B-16 MELANOMA .1. PRODUCTION, ISOLATION, STRUCTURE AND BIOLOGICAL-ACTIVITY
    SUGAWARA, K
    OHBAYASHI, M
    SHIMIZU, K
    HATORI, M
    KAMEI, H
    KONISHI, M
    OKI, T
    KAWAGUCHI, H
    [J]. JOURNAL OF ANTIBIOTICS, 1988, 41 (07) : 862 - 868
  • [10] SYNTHESIS AND ANTITUMOR-ACTIVITY OF TROPOLONE DERIVATIVES .7. BISTROPOLONES CONTAINING CONNECTING METHYLENE CHAINS
    YAMATO, M
    ANDO, J
    SAKAKI, K
    HASHIGAKI, K
    WATAYA, Y
    TSUKAGOSHI, S
    TASHIRO, T
    TSURUO, T
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (02) : 267 - 273
12