CLONING AND CHROMOSOMAL LOCALIZATION OF A HUMAN ENDOTHELIN ETA RECEPTOR

被引:50
作者
CYR, C
HUEBNER, K
DRUCK, T
KRIS, R
机构
[1] NYU MED CTR,DEPT PHARMACOL,550 1ST AVE,NEW YORK,NY 10016
[2] THOMAS JEFFERSON UNIV,JEFFERSON CANC INST,PHILADELPHIA,PA 19107
关键词
D O I
10.1016/S0006-291X(05)81399-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A cDNA clone encoding a human endothelin receptor was isolated from a placenta cDNA library. The deduced amino acid sequence of the clone is 94% identical to the bovine endothelin ETA receptor and represents the human homologue. The human endothelin ETA receptor gene was localized to chromosome 4 by analysis of its segregation pattern in rodent-human hybrids. © 1991 Academic Press, Inc.
引用
收藏
页码:184 / 190
页数:7
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