TETRAHYDROBIOPTERIN-DEPENDENT FORMATION OF ENDOTHELIUM-DERIVED RELAXING FACTOR (NITRIC-OXIDE) IN AORTIC ENDOTHELIAL-CELLS

被引：152

作者：

SCHMIDT, K ^{[1
]}

WERNER, ER ^{[1
]}

MAYER, B ^{[1
]}

WACHTER, H ^{[1
]}

KUKOVETZ, WR ^{[1
]}

机构：

[1] UNIV INNSBRUCK, A-6020 INNSBRUCK, AUSTRIA

来源：

BIOCHEMICAL JOURNAL | 1992年 / 281卷

关键词：

D O I：

10.1042/bj2810297

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inhibition of tetrahydrobiopterin (H4biopterin) biosynthesis in endothelial cells almost completely abolished the agonist-induced formation of endothelium-derived relaxing factor (EDRF) (NO). This inhibitory effect could be antagonized when H4biopterin biosynthesis was restored by activating a salvage pathway. These data indicate that the formation of EDRF strictly depends on the presence of intracellular H4biopterin, which, in addition to Ca2+, may represent a further physiological and/or pathophysiological regulatory of endothelial NO synthases.

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页码：297 / 300

页数：4

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