SECONDARILY REDUCED CYTOCHROME-C-OXIDASE ACTIVITY IN VARIOUS NEUROMUSCULAR DISORDERS

被引：6

作者：

OHTAKI, E ^{[1
]}

机构：

[1] KURUME UNIV,SCH MED,DEPT PEDIAT & CHILD HLTH,KURUME,FUKUOKA 830,JAPAN

来源：

BRAIN & DEVELOPMENT | 1990年 / 12卷 / 03期

关键词：

Cytochrome c oxidase; denervated muscle; mitochondrial myopathy; neuromuscular diseases; rat muscle;

D O I：

10.1016/S0387-7604(12)80315-9

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Decreased cytochrome c oxidase (CCO) activity was found in various neuromuscular diseases, including infantile spinal muscular atrophy (SMA) and Fukuyama type congenital muscular dystrophy (FCMD), that was thought to result from a secondarily induced mitochondrial defect. To determine whether or not the enzyme activities in the mitochondrial electron transport system can be secondarily changed, we measured the enzyme activities in denervated rat muscles. The CCO activity decreased progressively to 38–47% of the control value in 3 weeks after denervation, the NADH-cytochrome c reductase and succinate-cytochrome c reductase activities remaining unchanged, suggesting that the CCO activity may be easily reduced secondarily in various disease conditions. © 1990, All rights reserved.

引用

页码：326 / 333

页数：8

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