RECENT RESEARCH IN MARINE NATURAL-PRODUCTS - PUUPEHENONES

被引：78
作者：
RAVI, BN
PERZANOWSKI, HP
ROSS, RA
ERDMAN, TR
SCHEUER, PJ
FINER, J
CLARDY, J
机构：
[1] US DOE,AMES LAB,AMES,IA 50010
[2] IOWA STATE UNIV SCI & TECHNOL,DEPT CHEM,AMES,IA 50011
来源：
PURE AND APPLIED CHEMISTRY | 1979年 / 51卷 / 09期
基金：
美国国家科学基金会;
关键词：
D O I：
10.1351/pac197951091893
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Isolation and structural elucidation of three sponge metabolites, puupehenone (4) and its monochloro (11) and monobromo (12) derivatives is described. The compounds are products of mixed biosynthesis and consist of a C15 unrearranged drimane and a 1, 2, 4-trihydroxybenzene moiety. Halogen is incorporated in the aromatic part of the molecule and the chlorine isomer predominates over the bromine compound. The structures are based on spectral data and on single crystal x-ray diffraction of a C18 ozonolysis product (1) of puupehenone (4). Puupehenone (4) possesses moderate activity against gram-positive bacteria and against fungi. © IUPAC
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页码：1893 / 1900
页数：8
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