INFLUENCE OF THE 2ND AND 3RD GRADE ABSTRACTS FROM SCORPION-VENOM IN BUTHUS-MARTENSII KARSCH ON ACTION-POTENTIALS OF FAST-RESPONSE MYOCARDIOCYTES

被引：0

作者：

JIANG, Y ^{[1
]}

LIU, W ^{[1
]}

ZHONG, GG ^{[1
]}

YANG, SJ ^{[1
]}

ZHANG, WJ ^{[1
]}

WEI, JJ ^{[1
]}

ZHANG, HJ ^{[1
]}

WANG, L ^{[1
]}

机构：

[1] NORMAN BETHUNE UNIV MED SCI,DEPT ORGAN CHEM,CHANGCHUN 130021,PEOPLES R CHINA

来源：

ACTA PHARMACOLOGICA SINICA | 1995年 / 16卷 / 02期

关键词：

CULTURED CELLS; MYOCARDIUM; ACTION POTENTIALS; SCORPION VENOMS;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

AIM: To screen the active components of sodium channel blockade action from Buthus martensii Karsch (BMK) scorpion venom. METHOD: Myocardiocytes of mice were cultured. Action potentials of fast response myocardiocytes were recorded. The effects of 22 contents of BMK scorpion venom in a concentration of 3 mg . L(-1) were tested and compared with that of TTX 2.5 mg . L(-1), nimodipine (Nim) 3 mg . L(-1) and BaCl2 24.4 mg . L(-1). RESULTS: BMK-1 and other 19 contents significantly decreased depolarization parameters V-max, APA, OS, and MDP. which was similar to that of TTX and different from that of Nim and BaCl2. CONCLUSION: The variations in the action potentials of fast response myocardiolcytes indicated that 20 contents of BMK scorpion venom had sodium channel blockade action.

引用

页码：172 / 174

页数：3

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