The past several years have seen significant progress in understanding the role of T lymphocyte coreceptors in adhesion and activation. New insights have been gained in several areas: the avidity regulation of beta 1 and beta 2 integrins and their role in signal transduction; the regulation of CD8 avidity; the role of Lck in CD4 coreceptor activity; and the novel role for CD2 adhesion in the T cell antigen response.
机构:
UNIV SO CALIF, CTR REHABIL, SCH MED, DEPT MED, DIV RHEUMATOL, LOS ANGELES, CA 90024 USAUNIV SO CALIF, CTR REHABIL, SCH MED, DEPT MED, DIV RHEUMATOL, LOS ANGELES, CA 90024 USA