ANTERIOR-PITUITARY ADENYLATE-CYCLASE - STIMULATION BY DOPAMINE AND OTHER MONO-AMINES

被引：38
作者：
AHN, HS
GARDNER, E
MAKMAN, MH
机构：
[1] YESHIVA UNIV,ALBERT EINSTEIN COLL MED,DEPT MOLEC PHARMACOL,BRONX,NY 10461
[2] YESHIVA UNIV,ALBERT EINSTEIN COLL MED,DEPT PSYCHIAT,BRONX,NY 10461
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 53卷 / 03期
关键词：
Adenylate cyclase; Anterior pituitary; Apomorphine; Bromocriptine; Haloperidol; Lergotrile;
D O I：
10.1016/0014-2999(79)90139-0
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Adenylate cyclase activity of homogenates of anterior pituitary from rat, rabbit and monkey was stimulated by dopamine, other amine neurotransmitters and Gpp(NH)p. The concentration of dopamine for half-maximal stimulation of activity was 2-5 μM. Studies with selective agonists and antagonists indicated the presence of dopamine receptors and β-adrenergic receptors coupled to adenylate cyclase in anterior pituitary. In addition, histamine stimulated activity in rabbit and monkey, but not in rat, anterior pituitary. © 1979.
引用
收藏
页码：313 / 317
页数：5
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