EFFECT OF CRUDE EXTRACT OF ROOTS OF BREDEMEYERA-FLORIBUNDA WILLD .1. EFFECT ON ARTERIAL BLOOD-PRESSURE AND RENAL EXCRETION IN THE RAT

The infusion of the dried roots of Bredemeyera floribunda Willd. is used in Brazilian popular medicine as a potent diuretic, especially in the treatment- of hypertension and nephrolithiasis (renal calculi). Intravenous administration of crude root-extract (20-80 mg/kg) to anesthetized rats induces clear dose-dependent and reversible hypotensive responses. At higher doses the extract leads to bradycardia and death. In doses that do not alter the arterial blood pressure, the extract elicited immediate and dose-dependent reversible increase of water, sodium, and potassium renal excretion. The results, apart from indicating that the renal effect of the extract is not due to its systemic hypotensive action, support the folk therapeutic use of the infusion of the root-extract as a diuretic.