SERUM GASTRIN INCREASES WITH INCREASING DIETARY CALCIUM BUT NOT WITH INCREASING DIETARY-FAT OR FIBER IN FISCHER-344 RATS

被引:10
|
作者
FLOOR, MK
JAHANGEER, S
DAMBROSIO, C
ALABASTER, O
机构
[1] Institute/Disease Prevention, George Washington University, Medical Center, Washington
来源
JOURNAL OF NUTRITION | 1991年 / 121卷 / 06期
关键词
DIETARY CALCIUM; DIETARY FAT; DIETARY FIBER; GASTRIN; RATS;
D O I
10.1093/jn/121.6.863
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
We studied the effects of dietary calcium, fat and fiber on serum gastrin in Fischer-344 rats in a full factorial experiment as part of a larger study of diet and colon cancer risk factors. Nine- to 10-wk-old male rats were fed standard or experimental diets for 4 wk. Wheat bran was the sole source of fiber. Wheat bran levels were 0, 2.5, 10 and 20%; fat levels were 1, 5 and 10%; calcium levels were 0.18, 0.52 and 1.04% of diet weight. On d 29 serum was collected and stored at -80-degrees-C until analyzed. There was a significant (P < 0.0001) dose-dependent increase in serum gastrin from 102 to 173 ng/L, with increasing calcium. No other significant changes in serum gastrin were noted with the dietary changes. A long-term change in the level of serum gastrin, caused by dietary modification, will influence the trophic effect that gastrin has on colonic mucosa as well as on colon carcinomas. We speculate that calcium supplementation, although slowing colonic proliferation, might have an undesirable effect on the growth of early undetected colonic tumors.
引用
收藏
页码:863 / 868
页数:6
相关论文
共 50 条
  • [1] THE HYPERPROLIFERATIVE EFFECT OF INCREASING AMOUNTS OF DIETARY-FAT IS INHIBITED BY CALCIUM
    LAPRE, JA
    DEVRIES, HT
    VANDERMEER, R
    GASTROENTEROLOGY, 1993, 104 (04) : A419 - A419
  • [2] DIETARY-FAT TYPE ALTERS LIVER DIACYLGLYCEROL LEVELS IN FISCHER 344 RATS
    SWITZER, BR
    ZEISEL, SH
    FASEB JOURNAL, 1994, 8 (05): : A720 - A720
  • [3] LIVER PROTEIN-KINASE-C (PKC) LEVEL ALTERED BY DIETARY-FAT TYPE FED TO FISCHER-344 RATS
    SWITZER, BR
    TEW, B
    ZEISEL, SH
    FASEB JOURNAL, 1995, 9 (04): : A948 - A948
  • [4] CALCIUM DEPRIVATION INCREASES NACL INTAKE OF FISCHER-344 RATS
    TORDOFF, MG
    PHYSIOLOGY & BEHAVIOR, 1991, 49 (01) : 113 - 115
  • [5] Dietary Fat Composition Influences Tissue Lipid Profile and Gene Expression in Fischer-344 Rats
    Zhou, Albert L.
    Hintze, Korry J.
    Jimenez-Flores, Rafael
    Ward, Robert E.
    LIPIDS, 2012, 47 (12) : 1119 - 1130
  • [6] EFFECT OF DIETARY-FAT AND FIBER ON CALCIUM BIOAVAILABILITY
    KIES, C
    ACS SYMPOSIUM SERIES, 1985, 275 : 175 - 187
  • [7] ENHANCEMENT OF IRON-ABSORPTION IN IRON DEPLETED RATS BY INCREASING DIETARY-FAT
    BOWERING, J
    MASCH, GA
    LEWIS, AR
    JOURNAL OF NUTRITION, 1977, 107 (09): : 1687 - 1693
  • [8] INCREASING DIETARY-FAT INCREASES RAT HEPATIC GLUTATHIONE-S-TRANSFERASE ACTIVITY
    HENDRICH, S
    LEE, KW
    FASEB JOURNAL, 1992, 6 (04): : A1504 - A1504
  • [9] Dietary Milk Fat Globule Membrane Reduces the Incidence of Aberrant Crypt Foci in Fischer-344 Rats
    Snow, Dallin R.
    Jimenez-Flores, Rafael
    Ward, Robert E.
    Cambell, Jesse
    Young, Michael J.
    Nemere, Ilka
    Hintze, Korry J.
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2010, 58 (04) : 2157 - 2163
  • [10] The effect of dietary fat on malondialdehyde concentrations in Fischer 344 rats
    Danam, RP
    Lu, MH
    Lewis, SM
    Djuric, Z
    Tang, N
    Hart, RW
    MECHANISMS OF AGEING AND DEVELOPMENT, 1999, 110 (1-2) : 87 - 99