SOLUTION STRUCTURE OF HUMAN INSULIN-LIKE GROWTH FACTOR-I - A NUCLEAR-MAGNETIC-RESONANCE AND RESTRAINED MOLECULAR-DYNAMICS STUDY

被引：168
作者：
COOKE, RM [1 ]
HARVEY, TS [1 ]
CAMPBELL, ID [1 ]
机构：
[1] UNIV OXFORD,DEPT BIOCHEM,S PARKS RD,OXFORD OX1 3QU,ENGLAND
来源：
BIOCHEMISTRY | 1991年 / 30卷 / 22期
关键词：
D O I：
10.1021/bi00236a022
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The solution structure of human insulin-like growth factor 1 has been investigated with a combination of nuclear magnetic resonance and restrained molecular dynamics methods. The results show that the solution structure is similar to that of insulin, but minor differences exist. The regions homologous to insulin are well-defined, while the remainder of the molecule exhibits greater disorder. The resultant structures have been used to visualize the sites for interaction with a number of physiologically important proteins.
引用
收藏
页码：5484 / 5491
页数：8
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