STUDIES ON CARDIOTONIC AGENTS .2. SYNTHESIS OF NOVEL PHTHALAZINE AND 1,2,3-BENZOTRIAZINE DERIVATIVES

被引：173

作者：

NOMOTO, Y ^{[1
]}

OBASE, H ^{[1
]}

TAKAI, H ^{[1
]}

TERANISHI, M ^{[1
]}

NAKAMURA, J ^{[1
]}

KUBO, K ^{[1
]}

机构：

[1] KYOWA HAKKO KOGYO CO LTD, FUJI, PHARMACEUT RES LAB, NAGAIZUMI, SHIZUOKA 411, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1990年 / 38卷 / 08期

关键词：

2,3-benzotriazine; piperidine; positive inotropic activity cardiotonic agent structure-activity relationship phthalazine 1;

D O I：

10.1248/cpb.38.2179

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of phthalazine and 1,2,3-benzotriazine derivatives which have heterocyclylpiperidino groups was synthesized and tested for cardiotonic activity in anesthetized dogs. Several 6,7-dimethoxyphthalazine derivatives showed relatively potent cardiotonic activity comparable to that of amrinone. © 1990, The Pharmaceutical Society of Japan. All rights reserved.

引用

页码：2179 / 2183

页数：5

共 14 条

[1] BENZOCYCLOBUTENES .5. SYNTHESIS OF 4-HYDROXY-BENZOCYCLOBUTENE, 4,5-DIHYDROXY-BENZOCYCLOBUTENE, AND 3,6-DIHYDROXY-BENZOCYCLOBUTENE-1,2-DIONE (BENZOLOGUES OF SEMISQUARIC AND SQUARIC ACID) [J].

ABOUTEIM, O ;

JANSEN, RB ;

MCOMIE, JFW ;

PERRY, DH .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1980, (08) :1841-1846

[2]

ABUKI H, 1980, J LABELLED COMPD PHA, V6, P889

[3] RATIONALIZATION OF DRUG COMPLEXATION IN AQUEOUS-SOLUTION BY USE OF HUCKEL FRONTIER MOLECULAR-ORBITALS [J].

FAWZI, MB ;

DAVISON, E ;

TUTE, MS .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1980, 69 (01) :104-106

[4]

FOLLATH F, 1976, CLIN PHARMACOL THER, V20, P24

[5]

KATHAWALA FG, 1972, Patent No. 3678166

[6]

NOMOTO Y, 1990, CHEM PHARM BULL, V38, P1591

[7] SYNTHESIS OF CYCLIC GUANIDINES FUSED WITH AROMATIC RING THROUGH METAL-ION PROMOTED CYCLIZATION [J].

OBASE, H ;

NAKAMIZO, N ;

TAKAI, H ;

TERANISHI, M .

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1983, 56 (10) :3189-3190

[8] SYNTHESIS OF (1-SUBSTITUTED PIPERIDIN-4-YL)-1H-BENZIMIDAZOLES AND (1-SUBSTITUTED PIPERIDIN-4-YL)-3,4-DIHYDROQUINAZOLINES AS POSSIBLE ANTIHYPERTENSIVE AGENTS [J].

OBASE, H ;

TAKAI, H ;

TERANISHI, M ;

NAKAMIZO, N .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1983, 20 (03) :565-573

[9]

OBASE H, 1983, CHEM PHARM BULL, V31, P3186

[10]

PEDERSEN BS, 1978, B SOC CHIM BELG, V87, P223

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