STUDIES ON CARDIOTONIC AGENTS .2. SYNTHESIS OF NOVEL PHTHALAZINE AND 1,2,3-BENZOTRIAZINE DERIVATIVES

被引：172

作者：

NOMOTO, Y ^{[1
]}

OBASE, H ^{[1
]}

TAKAI, H ^{[1
]}

TERANISHI, M ^{[1
]}

NAKAMURA, J ^{[1
]}

KUBO, K ^{[1
]}

机构：

[1] KYOWA HAKKO KOGYO CO LTD, FUJI, PHARMACEUT RES LAB, NAGAIZUMI, SHIZUOKA 411, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1990年 / 38卷 / 08期

关键词：

2,3-benzotriazine; piperidine; positive inotropic activity cardiotonic agent structure-activity relationship phthalazine 1;

D O I：

10.1248/cpb.38.2179

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of phthalazine and 1,2,3-benzotriazine derivatives which have heterocyclylpiperidino groups was synthesized and tested for cardiotonic activity in anesthetized dogs. Several 6,7-dimethoxyphthalazine derivatives showed relatively potent cardiotonic activity comparable to that of amrinone. © 1990, The Pharmaceutical Society of Japan. All rights reserved.

引用

页码：2179 / 2183

页数：5

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