CONFORMATION AND IMMUNOGENICITY OF ENGINEERED REPEATING SEGMENT OF THE CIRCUMSPOROZOITE SURFACE PROTEIN OF PLASMODIUM-FALCIPARUM

被引：8
|
作者：
ARMAH, GE
NISHIKAWA, S
MIKI, S
OMATA, Y
NAKABAYASHI, T
TOMITA, K
机构：
[1] OSAKA UNIV,FAC PHARMACEUT SCI,1-6 YAMADAOKA,SUITA,OSAKA 565,JAPAN
[2] OSAKA UNIV,MICROBIAL DIS RES INST,OSAKA,JAPAN
来源：
MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 1990年 / 38卷 / 01期
关键词：
Conformation; Immunogenicity; Malaria vaccine; Plasmodium falciparum; Tetrapeptide;
D O I：
10.1016/0166-6851(90)90213-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Peptide vaccines based on units of the immunodominant tetrapeptide repeats, Asn-Ala-Asn-Pro and Asn-Val-Asp-Pro, of the circumsporozoite surface protein of the parasite Plasmodium falciparum are presently being developed as potential malaria vaccines. The N-terminal fusion of a hydrophobic protein to units of the tetrapeptide repeat affected the immunogenicity and conformational stability of the peptide, and also induced a secondary structure in the peptide. Peptide antigenicity, as well as conformational stability, was significantly increased. © 1990.
引用
收藏
页码：135 / 140
页数：6
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