A CONVENIENT SYNTHESIS OF 2-CYANOPYRROLES FROM ISOCYANOACETONITRILE

被引：17
作者：
ADAMCZYK, M
REDDY, RE
机构：
[1] Division Organic Chemistry Research (9NM, AP20), Diagnostics Division, Abbott Laboratories, Abbott Park, IL 60064-3500
来源：
TETRAHEDRON LETTERS | 1995年 / 36卷 / 44期
关键词：
D O I：
10.1016/0040-4039(95)01724-V
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
2-Cyano-3,4-substituted pyrroles 2a-e, important intermediates in the synthesis of porphyrins and related compounds, were prepared via base promoted condensation of alpha-acetoxynitro compound 1 alpha-e with isocyanoacetonitrile (3) in THF, in good yield.
引用
收藏
页码：7983 / 7986
页数：4
相关论文
共 31 条
[1]   THE REACTION OF BETA-AMINOENONES WITH ALPHA-AMINO DERIVATIVES - SYNTHESIS OF 2-FUNCTIONALIZED PYRROLES [J].
ALBEROLA, A ;
ANDRES, JM ;
GONZALEZ, A ;
PEDROSA, R ;
VICENTE, M .
HETEROCYCLES, 1990, 31 (06) :1049-1058
[2]  
[Anonymous], 1984, COMPREHENSIVE HETERO, DOI [10.1016/b978-008096519-2.00056-4, DOI 10.1016/B978-008096519-2.00056-4]
[3]  
BACKE F, 1970, LIEBIGS ANN CHEM, V735, P27
[4]  
BARTON DHR, 1990, TETRAHEDRON, V46, P7587
[5]   C-NUCLEOSIDE STUDIES .21. SYNTHESIS OF SOME HYDROXYALKYLATED PYRROLO[3,2-D]PYRIMIDINES AND THIENO-[3,2-D]PYRIMIDINES RELATED TO KNOWN ANTIVIRAL ACYCLONUCLEOSIDES [J].
BUCHANAN, JG ;
CRAVEN, DA ;
WIGHTMAN, RH ;
HARNDEN, MR .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1991, (01) :195-202
[6]   A CONVENIENT PREPARATION OF BENZYL 4-(R1)-3-(R2)PYRROLE-2-CARBOXYLATES [J].
BURNS, DH ;
JABARA, CS ;
BURDEN, MW .
SYNTHETIC COMMUNICATIONS, 1995, 25 (03) :379-387
[7]  
COHENE E, 1987, SYNTHESIS-STUTTGART, P566
[8]   PYRROLE CHEMISTRY .26. A SYNTHESIS OF PORPHOBILINOGEN FROM PYRROLE [J].
DEMOPOULOS, BJ ;
ANDERSON, HJ ;
LOADER, CE ;
FABER, K .
CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1983, 61 (10) :2415-2422
[9]  
DIXON J, 1989, Patent No. 300688
[10]  
Dolphin D., 1978, PORPHYRINS
1234