THE IONIC RESPONSE OF THE LIVER FLUKE, FASCIOLA-HEPATICA TO OUABAIN, MONENSIN AND THE DEACETYLATED (AMINE) METABOLITE OF DIAMPHENETHIDE

被引：3

作者：

CASEBY, RH

FAIRWEATHER, I ^{[1
]}

HARRIOTT, M

机构：

[1] QUEENS UNIV BELFAST,SCH BIOL & BIOCHEM,DAVID KEIR BLDG,BELFAST BT7 1NN,ANTRIM,NORTH IRELAND

[2] QUEENS UNIV BELFAST,SCH CHEM,BELFAST BT7 1NN,ANTRIM,NORTH IRELAND

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-PHYSIOLOGY | 1991年 / 100卷 / 04期

关键词：

D O I：

10.1016/0300-9629(91)90305-V

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. The ionic response of the liver fluke, Fasciola hepatica to perturbation of Na,K-pump activity has been determined by atomic absorption spectrophotometry. 2. The Na+/K+-ATPase inhibitor ouabain (1 x 10(-4) M) induced a marked reduction in K+ levels; Na+ and Ca2+ levels also fell. 3. The sodium ionophore monensin (1 x 10(-4) M) also caused a decrease in K+ levels, to below that of Na+. 4. Brief pretreatment with ouabain (1 x 10(-4) M, 15 min) followed by monensin treatment did not affect the decline in K+ levels, but did prevent the short-lived Na+ decline observed with monensin alone. 5. The deacetylated (amine) metabolite of the fasciolicide diamphenethide caused a short-lived drop in Na+ levels, but otherwise produced little change in ion levels within the fluke.

引用

页码：867 / 871

页数：5

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