A SOMATIC-CELL HYBRID MAP OF THE LONG ARM OF HUMAN CHROMOSOME-17, CONTAINING THE FAMILIAL BREAST-CANCER LOCUS (BRCAI)

被引：0

作者：

BLACK, DM ^{[1
]}

NICOLAI, H ^{[1
]}

BORROW, J ^{[1
]}

SOLOMON, E ^{[1
]}

机构：

[1] IMPERIAL CANC RES FUND,SOMAT CELL GENET LAB,LINCOLNS INN FIELDS,LONDON WC2A 3PX,ENGLAND

来源：

AMERICAN JOURNAL OF HUMAN GENETICS | 1993年 / 52卷 / 04期

关键词：

D O I：

暂无

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We describe a detailed somatic cell hybrid map of human chromosome 17q11.2-q23, containing the familial breast and ovarian cancer locus (BRCA1) and highly informative closely linked markers. An X-irradiation panel of 38 hamster/human and mouse/human hybrids with fragments of chromosome 17 was generated and characterized with 22 STS markers from this chromosome. A detailed map of 61 probes onto chromosome 17q, subdividing the chromosome arm into 25 regions, was done by using a panel of hybrids with well-defined breakpoints and nine chromosome-mediated gene transfectants. Our localization of RARA, TOP2, EDH17B1 and 2, and possibly WNT3, between THRA1 and D17S181, two markers known to flank BRCA1, suggests that any of these is a potential candidate for the BRCA1 locus. The marker D17S579 (Mfd188), which is believed to be very close to BRCA1, maps closest to the EDH17B genes.

引用

页码：702 / 710

页数：9

共 35 条

[1] A MONOCLONAL-ANTIBODY RECOGNIZING A CELL-SURFACE ANTIGEN CODED FOR BY A GENE ON HUMAN CHROMOSOME-17 [J].

BAI, Y ;

SHEER, D ;

HIORNS, L ;

KNOWLES, RW ;

TUNNACLIFFE, A .

ANNALS OF HUMAN GENETICS, 1982, 46 (OCT) :337-347

[2] GENETIC-MAPPING BASED ON RADIATION HYBRID DATA [J].

BARRETT, JH .

GENOMICS, 1992, 13 (01) :95-103

[3] A METHOD FOR GENERATING HYBRIDS CONTAINING NONSELECTED FRAGMENTS OF HUMAN-CHROMOSOMES [J].

BENHAM, F ;

HART, K ;

CROLLA, J ;

BOBROW, M ;

FRANCAVILLA, M ;

GOODFELLOW, PN .

GENOMICS, 1989, 4 (04) :509-517

[4]

BEVILACQUA G, 1989, CANCER RES, V49, P5185

[5]

BORROW J, 1990, GENOMICS, V10, P477

[6]

BOWCOCK AM, 1993, AM J HUM GENET, V52, P718

[7] ASSOCIATION OF NM23-H1 ALLELIC DELETIONS WITH DISTANT METASTASES IN COLORECTAL-CARCINOMA [J].

COHN, KH ;

WANG, FS ;

DESOTOLAPAIX, F ;

SOLOMON, WB ;

PATTERSON, LG ;

ARNOLD, MR ;

WEIMAR, J ;

FELDMAN, JG ;

LEVY, AT ;

LEONE, A ;

STEEG, PS .

LANCET, 1991, 338 (8769) :722-724

[8] PROGRESS TOWARDS IDENTIFYING THE NEUROFIBROMATOSIS (NF1) GENE [J].

COLLINS, FS ;

OCONNELL, P ;

PONDER, BAJ ;

SEIZINGER, BR .

TRENDS IN GENETICS, 1989, 5 (07) :217-221

[9] RADIATION HYBRID MAPPING - A SOMATIC-CELL GENETIC METHOD FOR CONSTRUCTING HIGH-RESOLUTION MAPS OF MAMMALIAN CHROMOSOMES [J].

COX, DR ;

BURMEISTER, M ;

PRICE, ER ;

KIM, S ;

MYERS, RM .

SCIENCE, 1990, 250 (4978) :245-250

[10] THE T(15-17) TRANSLOCATION OF ACUTE PROMYELOCYTIC LEUKEMIA FUSES THE RETINOIC ACID RECEPTOR-ALPHA GENE TO A NOVEL TRANSCRIBED LOCUS [J].

DETHE, H ;

CHOMIENNE, C ;

LANOTTE, M ;

DEGOS, L ;

DEJEAN, A .

NATURE, 1990, 347 (6293) :558-561

← 1 2 3 4 →