GENTAMICIN ADMINISTRATION VIA PERITONEAL-DIALYSIS FLUID - THE RISK OF OTOTOXICITY

被引：9

作者：

GENDEH, BS ^{[1
]}

SAID, H ^{[1
]}

GIBB, AG ^{[1
]}

AZIZ, NS ^{[1
]}

ZAHIR, ZM ^{[1
]}

机构：

[1] UNIV KEBANGSAAN MALAYSIA, FAC MED, DEPT EAR NOSE & THROAT, KUALA LUMPUR 50300, MALAYSIA

来源：

JOURNAL OF LARYNGOLOGY AND OTOLOGY | 1991年 / 105卷 / 12期

关键词：

OTOTOXICITY; GENTAMICIN; DIALYSIS; PERITONEAL;

D O I：

10.1017/S0022215100118055

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

In a prospective study on 47 patients, 16 mg of gentamicin per two litres dialysate was administered intraperitoneally at every cycle of intermittent peritoneal dialysis, carried out over the course of several days. Serum gentamicin sampling, pure tone audiometry and caloric tests were performed before and during the treatment. The gentamicin levels reached at the end of the thirtieth cycle were observed to be low. In view of this, the risk of acute ototoxicity was considered to be minimal. This was confirmed by the absence of clinical audiometric or vestibulometric evidence of toxicity.

引用

页码：999 / 1001

页数：3