ELLIPTICINES AS POTENT INHIBITORS OF MICROSOMES-DEPENDENT CHEMICAL MUTAGENESIS

被引：38

作者：

LESCA, P ^{[1
]}

LECOINTE, P ^{[1
]}

PAOLETTI, C ^{[1
]}

MANSUY, D ^{[1
]}

机构：

[1] ECOLE NORM SUPER, CHIM LAB, F-75231 PARIS 5, FRANCE

来源：

CHEMICO-BIOLOGICAL INTERACTIONS | 1979年 / 25卷 / 2-3期

关键词：

D O I：

10.1016/0009-2797(79)90052-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

9-Hydroxyellipticine (9-OHE), an inhibitor of microsomal monooxygenase activities has been shown to exert a large or even complete decrease of the mutagenicity, on the Salmonella strains of a great number of compounds (aromatic amines, polycyclic aromatic hydrocarbons, fungal toxins, azo compounds, tobacco smoke condensate). 9-OHE and 9-fluoroellipticine are more potent inhibitors than ellipticine itself. The inhibitions exerted by 9-OHE are not even equalled by 10-fold higher doses of 7,8-benzoflavone (7,8-BF). There is a good correlation between these data and the interaction properties of ellipticines with microsomal cytochromes P-450. © 1979.

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页码：279 / 287

页数：9

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