EGFR-Mutated Breast Metastasis of Lung Adenocarcinoma: A Case Report

被引：6

作者：

Dansin, Eric ^{[1
]}

Carnot, Aurelien ^{[1
]}

Servent, Veronique ^{[2
]}

Daussay, Dorothee ^{[3
]}

Robin, Yves-Marie ^{[3
]}

Surmei-Pintilie, Ecaterina ^{[5
]}

Lauridant, Geraldine ^{[1
,2
]}

Descarpentries, Clothilde ^{[6
]}

Revillion, Francoise ^{[4
,6
]}

Delattre, Claire ^{[7
]}

机构：

[1] CLCC Oscar Lambret, Dept Cancerol Gen, 3 Rue Frederic Combemale, FR-59020 Lille, France

[2] CLCC Oscar Lambret, Dept Senol, FR-59020 Lille, France

[3] CLCC Oscar Lambret, Unite Pathol Morphol & Mol, FR-59020 Lille, France

[4] CLCC Oscar Lambret, Unite Oncol Mol Humaine, FR-59020 Lille, France

[5] Hop A Calmette, Serv Chirurg Thorac, F-59037 Lille, France

[6] Plateforme Reg CHRU COL Genet Mol Canc, Lille, France

[7] CHRU Lille, Ctr Pathol, F-59037 Lille, France

来源：

CASE REPORTS IN ONCOLOGY | 2015年 / 8卷 / 01期

关键词：

Lung adenocarcinoma; Breast metastasis; EGFR mutation; Triple-negative breast cancer; EGFR tyrosine kinase inhibitors;

D O I：

10.1159/000381014

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Breast metastasis from other primary carcinoma is very rare and could be difficult to identify despite immunohistochemistry analysis. Breast metastasis from lung adenocarcinoma can mimic triple-negative breast cancer. Given the prognosis and therapeutic challenges, a correct diagnosis appears essential, and molecular biomarkers could be useful. We report the case of a 52-year-old woman with a breast mass initially diagnosed as primary breast cancer and secondarily attached to breast metastasis from an EGFR-mutated lung adenocarcinoma. The same activating EGFR mutations were identified in both the primary lung carcinoma and the breast metastasis. (C) 2015 S. Karger AG, Basel

引用

页码：164 / 168

页数：5

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