SPECIES-DIFFERENCES IN ADRENAL SPIRONOLACTONE METABOLISM - RELATIONSHIP TO CYTOCHROME-P-450 DESTRUCTION

被引:7
作者
SHERRY, JH [1 ]
JOHNSON, PB [1 ]
COLBY, HD [1 ]
机构
[1] UNIV ILLINOIS,COLL MED,DEPT BIOMED SCI,1601 PARKVIEW AVE,ROCKFORD,IL 61107
关键词
D O I
10.1016/0006-2952(88)90741-1
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:355 / 357
页数:3
相关论文
共 19 条
[1]   USE OF SPIRONOLACTONE IN DIAGNOSIS AND TREATMENT OF HYPERTENSION ASSOCIATED WITH MINERALOCORTICOID EXCESS [J].
BEEVERS, DG ;
BROWN, JJ ;
FERRISS, JB ;
FRASER, R ;
LEVER, AF ;
ROBERTSON, JI .
AMERICAN HEART JOURNAL, 1973, 86 (03) :404-414
[2]  
DAHLOF CG, 1979, DRUG METAB DISPOS, V7, P103
[3]  
GREINER JW, 1976, J PHARMACOL EXP THER, V198, P709
[4]   RELATION OF CANRENONE TO ACTIONS OF SPIRONOLACTONE ON ADRENAL CYTOCHROME P-450-DEPENDENT ENZYMES [J].
GREINER, JW ;
RUMBAUGH, RC ;
KRAMER, RE ;
COLBY, HD .
ENDOCRINOLOGY, 1978, 103 (04) :1313-1320
[5]   COMPARISON OF PLASMA-LEVELS OF CANRENONE AND METABOLITES AFTER BASE HYDROLYSIS IN YOUNG AND ELDERLY SUBJECTS FOLLOWING SINGLE AND MULTIPLE DOSES OF SPIRONOLACTONE [J].
HO, PC ;
BOURNE, DWA ;
TRIGGS, EJ ;
SMITHURST, BA .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1984, 27 (04) :435-439
[7]  
LOWRY OH, 1951, J BIOL CHEM, V193, P265
[8]   SPIRONOLACTONE AND CYTOCHROME-P-450 - IMPAIRMENT OF STEROID 21-HYDROXYLATION IN ADRENAL-CORTEX [J].
MENARD, RH ;
BARTTER, FC ;
GILLETTE, JR .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1976, 173 (02) :395-402
[9]  
MENARD RH, 1979, J BIOL CHEM, V254, P1726
[10]   EFFECT OF ADMINISTRATION OF SPIRONOLACTONE ON CONCENTRATION OF PLASMA TESTOSTERONE, ESTRADIOL AND CORTISOL IN MALE DOGS .1. [J].
MENARD, RH ;
LORIAUX, DL ;
BARTTER, FC ;
GILLETTE, JR .
STEROIDS, 1978, 31 (06) :771-782