PATTERN OF NEUROBEHAVIORAL DEFICITS ASSOCIATED WITH INTERFERON-ALFA THERAPY FOR LEUKEMIA

被引：136
作者：
PAVOL, MA
MEYERS, CA
REXER, JL
VALENTINE, AD
MATTIS, PJ
TALPAZ, M
机构：
[1] UNIV TEXAS,MD ANDERSON CANC CTR,DEPT NEUROONCOL,HOUSTON,TX 77030
[2] UNIV TEXAS,MD ANDERSON CANC CTR,DEPT CLIN IMMUNOL & BIOL THERAPY,HOUSTON,TX 77030
来源：
NEUROLOGY | 1995年 / 45卷 / 05期
关键词：
D O I：
10.1212/WNL.45.5.947
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
We evaluated the neuropsychological and personality profiles of 25 patients with chronic myelogenous leukemia treated with interferon alfa (IFN-alpha). This group of persons performed well below expectation on tests of cognitive speed, verbal memory, and executive functions. Personality changes included depression, increased somatic concern, and stress reactions. A control group of leukemia patients not treated with IFN-alpha had significantly better cognitive speed and mood. The pattern of cognitive and personality changes in patients receiving IFN-alpha is highly suggestive of frontal-subcortical brain dysfunction.
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页码：947 / 950
页数：4
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