ISOLATION AND STRUCTURE ELUCIDATION OF PERTHAMIDE-B, A NOVEL PEPTIDE FROM THE SPONGE THEONELLA SP

被引：16

作者：

GULAVITA, NK ^{[1
]}

POMPONI, SA ^{[1
]}

WRIGHT, AE ^{[1
]}

YARWOOD, D ^{[1
]}

SILLS, MA ^{[1
]}

机构：

[1] CIBA GEIGY CORP,DEPT RES,SUMMIT,NJ 07901

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 37期

关键词：

D O I：

10.1016/0040-4039(94)85012-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A sponge of the genus Theonella collected off Perth, Australia, contained a cyclic octapeptide. perthamide B, which weakly inhibited the binding of [I-125]IL-1 beta to intact EL4.6.1 cells with an IC50 of 27.6 mu M. The inhibition of binding could however, not be separated from the cytotoxic effects of perthamide B. The structure was elucidated by spectroscopic methods.

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页码：6815 / 6818

页数：4

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