INTERACTION OF CLOZAPINE WITH THE HISTAMINE H-3 RECEPTOR IN RAT-BRAIN

被引：31

作者：

RODRIGUES, AA ^{[1
]}

JANSEN, FP ^{[1
]}

LEURS, R ^{[1
]}

TIMMERMAN, H ^{[1
]}

PRELL, GD ^{[1
]}

机构：

[1] CUNY MT SINAI SCH MED,DEPT PHARMACOL,NEW YORK,NY 10029

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1995年 / 114卷 / 08期

关键词：

HISTAMINE H-3 RECEPTOR; CLOZAPINE; NEUROLEPTIC; RAT BRAIN SLICES; I-125] IODOPHENPROPIT; H-3] 5-HT RELEASE;

D O I：

10.1111/j.1476-5381.1995.tb14934.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We examined possible interactions between neuroleptics and the histamine H-3 receptor and found an interaction of clozapine with this receptor. In competition binding experiments, using the H-3 antagonist, [I-125]-iodophenpropit, we observed a K-i of 236 +/- 87 nM. Functionally, clozapine was studied on the H-3-mediated inhibition of [H-3]-5-hydroxytryptamine ([H-3]-5-HT) release from fat brain cortex slices. Clozapine acts as an antagonist with an apparent K-B value of 79.5 nM.

引用

页码：1523 / 1524

页数：2

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