ATOMIC-EMISSION SPECTROMETRIC DETERMINATION OF ANTAZOLINE, HYDRALAZINE, AMILORIDE, THIAMINE AND QUININE BASED ON FORMATION OF ION ASSOCIATES WITH AMMONIUM REINECKATE

Ion-associate complexes of Antazoline HCl (I), Hydralazine HCl (II), Amiloride HCl (III), Thiamine HCl (IV) and Quinine sulphate (V) with ammonium reineckate were precipitated and their solubilities were studied as a function of pH, ionic strength and temperature. Saturated solutions of each ion-associate under the optimum precipitation conditions were prepared and the metal ion-content in the supernatent was determined. The solubility products were thus elucidated at different temperatures. A new accurate and precise method using direct coupled plasma-atomic emission spectrometry for the determination of the investigated drugs in pure solutions and in pharmaceutical preparations is described. The drugs can be determined by the present method in the ranges 0.3-3.0, 0.19-1.96, 0.3-3.0, 0.33-3.37 and 0.78-7.82 mg/25 ml solutions of I, II, III, IV and V, respectively.