THE ROLE OF GP39 (CD40L) IN IMMUNITY

被引：18

作者：

NOELLE, RJ

机构：

[1] Department of Microbiology, Dartmouth Medical School, Lebanon

来源：

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY | 1995年 / 76卷 / 03期

关键词：

D O I：

10.1016/S0090-1229(95)90234-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The function of CD40 and its ligand (CD40L;gp39) has provided a molecular understanding for cognate interactions and the basis for hyper IgM syndrome. Studies using an antibody that neutralizes gp39 function in vivo have demonstrated that interactions between CD40 and gp39 are essential for primary and secondary thymus-dependent humoral immune responses, as well as for the generation of memory B cells. In addition, gp39 is critical for B cells to upregulate important costimulatory molecules and acquire professional antigen-presenting cell status. If B cells do not receive the gp39 signal, they are rendered tolerogenic for T cells. Finally, gp39-CD40 interactions are important in thymic education since blockade of this interaction interrupts negative selection. (C) 1995 Academic Press, Inc.

引用

收藏

页码：S203 / S207

页数：5

相关论文

共 28 条

[1] CD40 LIGAND GENE DEFECTS RESPONSIBLE FOR X-LINKED HYPER-IGM SYNDROME [J].

ALLEN, RC ;

ARMITAGE, RJ ;

CONLEY, ME ;

ROSENBLATT, H ;

JENKINS, NA ;

COPELAND, NG ;

BEDELL, MA ;

EDELHOFF, S ;

DISTECHE, CM ;

SIMONEAUX, DK ;

FANSLOW, WC ;

BELMONT, J ;

SPRIGGS, MK .

SCIENCE, 1993, 259 (5097) :990-993

[2] IDENTIFICATION OF A SOURCE OF BIOLOGICALLY-ACTIVE CD40 LIGAND [J].

ARMITAGE, RJ ;

SATO, TA ;

MACDUFF, BM ;

CLIFFORD, KN ;

ALPERT, AR ;

SMITH, CA ;

FANSLOW, WC .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1992, 22 (08) :2071-2076

[3] MOLECULAR AND BIOLOGICAL CHARACTERIZATION OF A MURINE LIGAND FOR CD40 [J].

ARMITAGE, RJ ;

FANSLOW, WC ;

STROCKBINE, L ;

SATO, TA ;

CLIFFORD, KN ;

MACDUFF, BM ;

ANDERSON, DM ;

GIMPEL, SD ;

DAVISSMITH, T ;

MALISZEWSKI, CR ;

CLARK, EA ;

SMITH, CA ;

GRABSTEIN, KH ;

COSMAN, D ;

SPRIGGS, MK .

NATURE, 1992, 357 (6373) :80-82

[4]

ARUFFO A, CELL, V72, P291

[5] THE CD40 ANTIGEN AND ITS LIGAND [J].

BANCHEREAU, J ;

BAZAN, F ;

BLANCHARD, D ;

BRIERE, F ;

GALIZZI, JP ;

VANKOOTEN, C ;

LIU, YJ ;

ROUSSET, F ;

SAELAND, S .

ANNUAL REVIEW OF IMMUNOLOGY, 1994, 12 :881-922

[6]

BARTLETT WC, 1990, J IMMUNOL, V145, P3956

[7]

CASCAN H, 1992, EUR J IMMUNOL, V22, P1133

[8] CD40 LIGAND MUTATIONS IN X-LINKED IMMUNODEFICIENCY WITH HYPER-IGM [J].

DISANTO, JP ;

BONNEFOY, JY ;

GAUCHAT, JF ;

FISCHER, A ;

DESAINTBASILE, G .

NATURE, 1993, 361 (6412) :541-543

[9] SMALL B-CELLS AS ANTIGEN-PRESENTING CELLS IN THE INDUCTION OF TOLERANCE TO SOLUBLE-PROTEIN ANTIGENS [J].

EYNON, EE ;

PARKER, DC .

JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 175 (01) :131-138

[10] IN-VIVO CD40-GP39 INTERACTIONS ARE ESSENTIAL FOR THYMUS-DEPENDENT HUMORAL IMMUNITY .2. PROLONGED SUPPRESSION OF THE HUMORAL IMMUNE-RESPONSE BY AN ANTIBODY TO THE LIGAND FOR CD40, GP39 [J].

FOY, TM ;

SHEPHERD, DM ;

DURIE, FH ;

ARUFFO, A ;

LEDBETTER, JA ;

NOELLE, RJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (05) :1567-1575