OPIOID RECEPTOR REGULATION OF 5-HYDROXYTRYPTAMINE RELEASE FROM THE RAT HIPPOCAMPUS MEASURED BY INVIVO MICRODIALYSIS

被引:39
|
作者
YOSHIOKA, M [1 ]
MATSUMOTO, M [1 ]
TOGASHI, H [1 ]
SMITH, CB [1 ]
SAITO, H [1 ]
机构
[1] UNIV MICHIGAN,SCH MED,DEPT PHARMACOL,ANN ARBOR,MI 48109
关键词
OPIOID RECEPTOR; MORPHINE; DPDPE; U-69593; SEROTONIN; HIPPOCAMPUS; INVIVO MICRODIALYSIS; RAT;
D O I
10.1016/0006-8993(93)90456-W
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The modulation of serotonin (5-HT) release by opioid receptors in the hippocampus of the awake, unrestrained rat was evaluated by use of in vivo microdialysis. The hippocampus was perfused with Ringer's solution (2 mul/min), and extracellular levels of 5-HT and its major metabolite, 5-hydroxyindoleacetic acid (5-HIAA) were estimated by assaying their concentration in the dialysate by HPLC-ECD. Addition of potassium (K+, 60 and 120 mM) to the perfusate evoked a concentration-dependent release of 5-HT, but did not alter extracellular 5-HIAA levels. Co-perfusion of morphine (0.1 to 10 muM) with K+ (120 mM) produced a concentration-dependent reduction of 5-HT release. Naltrexone (0.03 to 3 mg/kg, i.p.), a relatively selective mu-opioid receptor antagonist, blocked in a dose-dependent manner the morphine (10 muM)-induced inhibition of 5-HT release. Naltrexone alone did not alter significantly either extracellular 5-HT levels or the release of 5-HT evoked by K+. Neither co-perfusion With [D-Pen2, D-Pen5]-enkephalin (DPDPE, 1 to 10 muM), an agonist selective for delta-opioid receptors, nor with U-69593 (10 muM), an agonist selective for kappa-opioid receptors, modified the K+ (120 mM)-evoked release of 5-HT. These findings indicate that mu-opioid receptors modulate the physiological release of 5-HT from serotonergic neurons in the rat hippocampus.
引用
收藏
页码:74 / 79
页数:6
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