INDUCTION OF BRADYZOITE-SPECIFIC TOXOPLASMA-GONDII ANTIGENS IN GAMMA-INTERFERON-TREATED MOUSE MACROPHAGES

被引：125
|
作者：
BOHNE, W [1 ]
HEESEMANN, J [1 ]
GROSS, U [1 ]
机构：
[1] UNIV WURZBURG,INST HYG & MICROBIOL,JOSEF SCHNEIDER STR 2,W-8700 WURZBURG,GERMANY
来源：
INFECTION AND IMMUNITY | 1993年 / 61卷 / 03期
关键词：
D O I：
10.1128/IAI.61.3.1141-1145.1993
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
By using stage-specific monoclonal antibodies, an in vitro model has been developed to analyze the kinetics of expression of stage-specific antigens during the conversion process between tachyzoites and bradyzoites of Toxoplasma gondii. Following infection of murine macrophages with bradyzoites, the expression of bradyzoite-specific antigens declined, whereas the expression of tachyzoite-specific antigens increased during the first 72 h postinfection. Conversely, in gamma interferon-treated murine macrophages infected with tachyzoites, the inhibitory effect of gamma interferon on replication of parasites was accompanied by the induction of bradyzoite-specific antigens.
引用
收藏
页码：1141 / 1145
页数：5
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