INDUCTION OF BRADYZOITE-SPECIFIC TOXOPLASMA-GONDII ANTIGENS IN GAMMA-INTERFERON-TREATED MOUSE MACROPHAGES

被引：126

作者：

BOHNE, W ^{[1
]}

HEESEMANN, J ^{[1
]}

GROSS, U ^{[1
]}

机构：

[1] UNIV WURZBURG,INST HYG & MICROBIOL,JOSEF SCHNEIDER STR 2,W-8700 WURZBURG,GERMANY

来源：

INFECTION AND IMMUNITY | 1993年 / 61卷 / 03期

关键词：

D O I：

10.1128/IAI.61.3.1141-1145.1993

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

By using stage-specific monoclonal antibodies, an in vitro model has been developed to analyze the kinetics of expression of stage-specific antigens during the conversion process between tachyzoites and bradyzoites of Toxoplasma gondii. Following infection of murine macrophages with bradyzoites, the expression of bradyzoite-specific antigens declined, whereas the expression of tachyzoite-specific antigens increased during the first 72 h postinfection. Conversely, in gamma interferon-treated murine macrophages infected with tachyzoites, the inhibitory effect of gamma interferon on replication of parasites was accompanied by the induction of bradyzoite-specific antigens.

引用

页码：1141 / 1145

页数：5

共 31 条

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