INDUCTION OF BRADYZOITE-SPECIFIC TOXOPLASMA-GONDII ANTIGENS IN GAMMA-INTERFERON-TREATED MOUSE MACROPHAGES

被引：126

作者：

BOHNE, W ^{[1
]}

HEESEMANN, J ^{[1
]}

GROSS, U ^{[1
]}

机构：

[1] UNIV WURZBURG,INST HYG & MICROBIOL,JOSEF SCHNEIDER STR 2,W-8700 WURZBURG,GERMANY

来源：

INFECTION AND IMMUNITY | 1993年 / 61卷 / 03期

关键词：

D O I：

10.1128/IAI.61.3.1141-1145.1993

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

By using stage-specific monoclonal antibodies, an in vitro model has been developed to analyze the kinetics of expression of stage-specific antigens during the conversion process between tachyzoites and bradyzoites of Toxoplasma gondii. Following infection of murine macrophages with bradyzoites, the expression of bradyzoite-specific antigens declined, whereas the expression of tachyzoite-specific antigens increased during the first 72 h postinfection. Conversely, in gamma interferon-treated murine macrophages infected with tachyzoites, the inhibitory effect of gamma interferon on replication of parasites was accompanied by the induction of bradyzoite-specific antigens.

引用

页码：1141 / 1145

页数：5

共 31 条

[1]

ADAMS LB, 1990, J IMMUNOL, V144, P2725

[2]

BURG JL, 1988, J IMMUNOL, V141, P3584

[3]

CHANG HR, 1990, IMMUNOLOGY, V69, P33

[4] SEPARATION OF ISOSPORA (TOXOPLASMA) GONDII CYSTS AND CYSTOZOITES FROM MOUSE-BRAIN TISSUE BY CONTINUOUS DENSITY-GRADIENT CENTRIFUGATION [J].

CORNELISSEN, AWCA ;

OVERDULVE, JP ;

HOENDERBOOM, JM .

PARASITOLOGY, 1981, 83 (AUG) :103-&

[5]

DUBREMETZ JF, COMMUNICATION

[6] IDENTIFICATION OF A VIRULENCE-ASSOCIATED ANTIGEN OF TOXOPLASMA-GONDII BY USE OF A MOUSE MONOCLONAL-ANTIBODY [J].

GROSS, U ;

MULLER, WA ;

KNAPP, S ;

HEESEMANN, J .

INFECTION AND IMMUNITY, 1991, 59 (12) :4511-4516

[7] MONOCLONAL-ANTIBODIES DIRECTED AGAINST PLASMID-ENCODED RELEASED PROTEINS OF ENTEROPATHOGENIC YERSINIA [J].

HEESEMANN, J ;

KALTHOFF, H ;

KOCH, F .

FEMS MICROBIOLOGY LETTERS, 1986, 36 (01) :15-19

[8] A PROTECTIVE ROLE FOR ENDOGENOUS TUMOR-NECROSIS-FACTOR IN TOXOPLASMA-GONDII INFECTION [J].

JOHNSON, LL .

INFECTION AND IMMUNITY, 1992, 60 (05) :1979-1983

[9]

KASPER LH, 1983, J IMMUNOL, V130, P2407

[10] CLEAVAGE OF STRUCTURAL PROTEINS DURING ASSEMBLY OF HEAD OF BACTERIOPHAGE-T4 [J].

LAEMMLI, UK .

NATURE, 1970, 227 (5259) :680-+

← 1 2 3 4 →