LINKAGE STUDY OF SCHIZOPHRENIA WITH MARKERS ON CHROMOSOME-11 IN 2 JAPANESE PEDIGREES

被引：0

作者：

NANKO, S

GILL, M

OWEN, M

TAKAZAWA, N

MORIDAIRA, J

KAZAMATSURI, H

机构：

[1] UNIV LONDON,INST PSYCHIAT,DEPT PSYCHIAT,GENET SECT,LONDON,ENGLAND

[2] UNIV WALES COLL MED,DEPT PSYCHOL MED,CARDIFF CF4 4XN,S GLAM,WALES

来源：

JAPANESE JOURNAL OF PSYCHIATRY AND NEUROLOGY | 1992年 / 46卷 / 01期

基金：

英国医学研究理事会;

关键词：

LINKAGE; SCHIZOPHRENIA; DNA MARKER; CHROMOSOME-11; D11S35;

D O I：

暂无

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined the linkage between schizophrenia and DNA markers on chromosome 11 in two Japanese pedigrees. Thirty individuals from the two pedigrees were genotyped at the eleven polymorphisms (eight loci) studied. Data were analysed according to three models, representing a range of single gene models from near dominant to an intermediate model. For all markers, except those at the D11S35 locus, there is no evidence for the linkage. Positive LOD scores between 1 and 1.5 are obtained for some genetic models with the polymorphism at D11S35. Two point scores for the broad diagnostic model and for the intermediate parameter set peak at 1.49.

引用

页码：155 / 159

页数：5

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