LINKAGE STUDY OF SCHIZOPHRENIA WITH MARKERS ON CHROMOSOME-11 IN 2 JAPANESE PEDIGREES

被引：0

作者：

NANKO, S

GILL, M

OWEN, M

TAKAZAWA, N

MORIDAIRA, J

KAZAMATSURI, H

机构：

[1] UNIV LONDON,INST PSYCHIAT,DEPT PSYCHIAT,GENET SECT,LONDON,ENGLAND

[2] UNIV WALES COLL MED,DEPT PSYCHOL MED,CARDIFF CF4 4XN,S GLAM,WALES

来源：

JAPANESE JOURNAL OF PSYCHIATRY AND NEUROLOGY | 1992年 / 46卷 / 01期

基金：

英国医学研究理事会;

关键词：

LINKAGE; SCHIZOPHRENIA; DNA MARKER; CHROMOSOME-11; D11S35;

D O I：

暂无

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined the linkage between schizophrenia and DNA markers on chromosome 11 in two Japanese pedigrees. Thirty individuals from the two pedigrees were genotyped at the eleven polymorphisms (eight loci) studied. Data were analysed according to three models, representing a range of single gene models from near dominant to an intermediate model. For all markers, except those at the D11S35 locus, there is no evidence for the linkage. Positive LOD scores between 1 and 1.5 are obtained for some genetic models with the polymorphism at D11S35. Two point scores for the broad diagnostic model and for the intermediate parameter set peak at 1.49.

引用

页码：155 / 159

页数：5

共 50 条

[31] Further evidence for a susceptibility locus on chromosome 10p14-p11 in 72 families with schizophrenia by nonparametric linkage analysis [J].

Schwab, SG ;

Hallmayer, J ;

Albus, M ;

Lerer, B ;

Hanses, C ;

Kanyas, K ;

Segman, R ;

Borrman, M ;

Dreikorn, B ;

Lichtermann, D ;

Rietschel, M ;

Trixler, M ;

Maier, W ;

Wildenauer, DB .

AMERICAN JOURNAL OF MEDICAL GENETICS, 1998, 81 (04) :302-307

[32] Association study of H2AFZ with schizophrenia in a Japanese case-control sample [J].

Jitoku, Daisuke ;

Yamamoto, Naoki ;

Iwayama, Yoshimi ;

Toyota, Tomoko ;

Miyagi, Momo ;

Enokida, Takeshi ;

Tasaka, Yuri ;

Umino, Masakazu ;

Umino, Asami ;

Uezato, Akihito ;

Iwata, Yasuhide ;

Suzuki, Katsuaki ;

Kikuchi, Mitsuru ;

Hashimoto, Tasuku ;

Kanahara, Nobuhisa ;

Kurumaji, Akeo ;

Yoshikawa, Takeo ;

Nishikawa, Toru .

JOURNAL OF NEURAL TRANSMISSION, 2015, 122 (06) :915-923

[33] Family-based association study of markers on chromosome 22 in schizophrenia using African-American, European-American, and Chinese families [J].

Takahashi, S ;

Cui, YH ;

Kojima, T ;

Han, YH ;

Zhou, RL ;

Kamioka, M ;

Yu, SY ;

Matsuura, M ;

Matsushima, E ;

Wilcox, M ;

Arinami, T ;

Shen, YC ;

Faraone, SV ;

Tsuang, MT .

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2003, 120B (01) :11-17

[34] A study of chromosome 4p markers and dopamine D5 receptor gene in schizophrenia and bipolar disorder [J].

Asherson, P ;

Mant, R ;

Williams, N ;

Cardno, A ;

Jones, L ;

Murphy, K ;

Collier, DA ;

Nanko, S ;

Craddock, N ;

Morris, S ;

Muir, W ;

Blackwood, B ;

McGuffin, P ;

Owen, MJ .

MOLECULAR PSYCHIATRY, 1998, 3 (04) :310-320

[35] A study of chromosome 4p markers and dopamine D5 receptor gene in schizophrenia and bipolar disorder [J].

P Asherson ;

R Mant ;

N Williams ;

A Cardno ;

L Jones ;

K Murphy ;

D A Collier ;

S Nanko ;

N Craddock ;

S Morris ;

W Muir ;

B Blackwood ;

P McGuffin ;

M J Owen .

Molecular Psychiatry, 1998, 3 :310-320

[36] Chromosome 14 linkage analysis and mutation study of 2 serpin genes in allergic asthmatic families [J].

Malerba, G ;

Patuzzo, C ;

Trabetti, E ;

Lauciello, MC ;

Galavotti, R ;

Pescollderungg, L ;

Whalen, MB ;

Zanoni, G ;

Martinati, LC ;

Boner, AL ;

Pignatti, PF .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2001, 107 (04) :654-658

[37] Association Analysis of the PIP4K2A Gene on Chromosome 10p12 and Schizophrenia in the Irish Study of High Density Schizophrenia Families (ISHDSF) and the Irish Case-Control Study of Schizophrenia (ICCSS) [J].

Thiselton, D. L. ;

Maher, B. S. ;

Webb, B. T. ;

Bigdeli, T. B. ;

O'Neill, F. A. ;

Walsh, D. ;

Kendler, K. S. ;

Riley, B. P. .

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2010, 153B (01) :323-331

[38] Association study of H2AFZ with schizophrenia in a Japanese case–control sample [J].

Daisuke Jitoku ;

Naoki Yamamoto ;

Yoshimi Iwayama ;

Tomoko Toyota ;

Momo Miyagi ;

Takeshi Enokida ;

Yuri Tasaka ;

Masakazu Umino ;

Asami Umino ;

Akihito Uezato ;

Yasuhide Iwata ;

Katsuaki Suzuki ;

Mitsuru Kikuchi ;

Tasuku Hashimoto ;

Nobuhisa Kanahara ;

Akeo Kurumaji ;

Takeo Yoshikawa ;

Toru Nishikawa .

Journal of Neural Transmission, 2015, 122 :915-923

[39] Association study of interleukin 2 (IL2) and IL4 with schizophrenia in a Japanese population [J].

Watanabe, Yuichiro ;

Nunokawa, Ayako ;

Shibuya, Masako ;

Kaneko, Naoshi ;

Nawa, Hiroyuki ;

Someya, Toshiyuki .

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, 2008, 258 (07) :422-427

[40] Association study of interleukin 2 (IL2) and IL4 with schizophrenia in a Japanese population [J].

Yuichiro Watanabe ;

Ayako Nunokawa ;

Masako Shibuya ;

Naoshi Kaneko ;

Hiroyuki Nawa ;

Toshiyuki Someya .

European Archives of Psychiatry and Clinical Neuroscience, 2008, 258 :422-427

← 1 2 3 4 5 →