REGULATION OF THE LEVEL OF UNCOUPLING PROTEIN IN BROWN ADIPOSE-TISSUE BY INSULIN REQUIRES THE MEDIATION OF THE SYMPATHETIC NERVOUS-SYSTEM

被引：43
|
作者：
GELOEN, A
TRAYHURN, P
机构：
[1] ROWETT RES INST,DIV BIOCHEM SCI,BUCKSBURN AB2 9SB,ABERDEEN,SCOTLAND
[2] LAB THERMOREGULAT & ENERGET EXERCISE,URA 1341,F-69373 LYONS,FRANCE
来源：
FEBS LETTERS | 1990年 / 267卷 / 02期
关键词：
Brown adipose tissue; Diabetes; Insulin; Noradrenaline; Sympathetic nervous system; Uncoupling protein;
D O I：
10.1016/0014-5793(90)80941-B
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The role of the sympathetic nervous system in the regulation by insulin of the level of uncoupling protein in brown adipose tissue has been examined. The amount of uncoupling protein was substantially reduced in streptozotocin-diabetic rats, while insulin replacement to diabetic animals induced a partial restoration. Unilateral denervation of the interscapular brown fat pads also lowered the amount of uncoupling protein, and in diabetic animals inhibited the stimulation of the level of the protein by insulin replacement. Maintenance of normal uncoupling protein levels requires both insulin and the sympathetic system; regulation of the protein by insulin involves sympathetic mediation. © 1990.
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页码：265 / 267
页数：3
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