GAS-PHASE PROTON AFFINITY OF DEOXYRIBONUCLEOSIDES AND RELATED NUCLEOBASES BY FAST-ATOM-BOMBARDMENT TANDEM MASS-SPECTROMETRY

被引：218

作者：

GRECO, F ^{[1
]}

LIGUORI, A ^{[1
]}

SINDONA, G ^{[1
]}

UCCELLA, N ^{[1
]}

机构：

[1] UNIV CALABRIA, DIPARTIMENTO CHIM, I-87030 ARCAVACATA, ITALY

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1990年 / 112卷 / 25期

关键词：

D O I：

10.1021/ja00181a009

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The proton affinities (PA) of the deoxynucleosides and nucleobases present in DNA's have been determined from the kinetics of the gas-phase unimolecular dissociations of their proton-bound hetero-complexes with amines of known PA. The clusters have been formed by fast-atom-bombardment mass spectrometry from different matrices, whose effect has been evaluated. The experimentally determined order dG > dA ≅ dC ≫ dT differs from that of the corresponding pyrimidine and purine bases, Gua > Cyt > Ade ≫ Thy, and from that of the same nucleosides in aqueous solutions. © 1990, American Chemical Society. All rights reserved.

引用

页码：9092 / 9096

页数：5

共 30 条

[1] QUANTITATIVE PROTON AFFINITIES, IONIZATION-POTENTIALS, AND HYDROGEN AFFINITIES OF ALKYLAMINES [J].