IGG AUTOANTIBODIES AGAINST C1Q ARE CORRELATED WITH NEPHRITIS, HYPOCOMPLEMENTEMIA, AND DSDNA ANTIBODIES IN SYSTEMIC LUPUS-ERYTHEMATOSUS

被引：0

作者：

SIEGERT, C ^{[1
]}

DAHA, M ^{[1
]}

WESTEDT, ML ^{[1
]}

VANDERVOORT, E ^{[1
]}

BREEDVELD, F ^{[1
]}

机构：

[1] UNIV HOSP LEIDEN,DEPT NEPHROL,2300 RC LEIDEN,NETHERLANDS

来源：

JOURNAL OF RHEUMATOLOGY | 1991年 / 18卷 / 02期

关键词：

C1Q ANTIBODIES; LUPUS NEPHRITIS; SYSTEMIC LUPUS ERYTHEMATOSUS;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We investigated the association between serum titers of IgG antibodies against Clq (ClqAb) and clinical and laboratory variables of disease activity in systemic lupus erythematosus (SLE). ClqAb were measured by ELISA in serum samples of 88 patients. Thirty patients (34%) had increased ClqAb titers. No correlation between ClqAb titers and a score for general disease activity was found. However, significant positive correlations were found between ClqAb titers and the presence of several clinical and laboratory variables of disease activity. These included nephritis, dermatitis, hypocomplementemia, antibodies against dsDNA, and circulating immune complexes. A negative correlation was found with neurological disease manifestations. The correlations between ClqAb titers and clinical features indicate that the pathogenetic role for ClqAb in certain disease manifestations of SLE deserves further study.

引用

页码：230 / 234

页数：5

共 50 条

[41] IGG HUMAN MONOCLONAL ANTI-DNA AUTOANTIBODIES FROM PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS [J].

WINKLER, TH ;

JAHN, S ;

KALDEN, JR .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 1991, 85 (03) :379-385

[42] Anti-C1q in systemic lupus erythematosus [J].

Stojan, G. ;

Petri, M. .

LUPUS, 2016, 25 (08) :873-877

[43] ANTI-DSDNA ANTIBODIES IN LABORATORY WORKERS HANDLING BLOOD FROM PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS [J].

ZARMBINSKI, MA ;

MESSNER, RP ;

MANDEL, JS .

JOURNAL OF RHEUMATOLOGY, 1992, 19 (09) :1380-1384

[44] Clearance of dying cells and systemic lupus erythematosus: the role of C1q and the complement system [J].

Dror Mevorach .

Apoptosis, 2010, 15 :1114-1123

[45] Clearance of dying cells and systemic lupus erythematosus: the role of C1q and the complement system [J].

Mevorach, Dror .

APOPTOSIS, 2010, 15 (09) :1114-1123

[46] Epitope-Specific Anti-C1q Autoantibodies in Systemic Lupus Erythematosus [J].

Kleer, Jessica S. ;

Rabatscher, Pascal A. ;

Weiss, Jessica ;

Leonardi, Joel ;

Vogt, Severin B. ;

Kieninger-Grafitsch, Andrea ;

Chizzolini, Carlo ;

Huynh-Do, Uyen ;

Ribi, Camillo ;

Trendelenburg, Marten .

FRONTIERS IN IMMUNOLOGY, 2022, 12

[47] Anti-C1q and anti-dsDNA antibodies in systemic lupus erythematosus: Relationship with disease activity and renal involvement in Sharkia governorate, Egypt [J].

El-Hewala, A. ;

Nageeb, Ghada S. ;

El-shahawy, Eman E. ;

Sharaf, Doaa M. ;

Omran, Alaa A. ;

El-Messallamy, Fawzy A. F. ;

Eassa, Shereen .

EGYPTIAN RHEUMATOLOGIST, 2011, 33 (04) :203-208

[48] Anti-dsDNA antibodies in Brazilian patients of mainly African descent with systemic lupus erythematosus: lack of association with lupus nephritis [J].

Atta, A. M. ;

Pereira, M. M. ;

Santiago, M. ;

Sousa-Atta, M. L. B. .

CLINICAL RHEUMATOLOGY, 2009, 28 (06) :693-697

[49] Anti-dsDNA antibodies in Brazilian patients of mainly African descent with systemic lupus erythematosus: lack of association with lupus nephritis [J].

A. M. Atta ;

M. M. Pereira ;

M. Santiago ;

M. L. B. Sousa-Atta .

Clinical Rheumatology, 2009, 28 :693-697

[50] Anti-C1q antibodies and systemic lupus erythematosus in the Tunisian population [J].

Trad, B. ;

Ben Hassine, H. ;

Khalifa, M. ;

Idriss, N. ;

Slama, F. ;

Bahri, F. ;

Kechrid, C. Laouani ;

Boukadida, J. ;

Sghiri, R. .

PATHOLOGIE BIOLOGIE, 2013, 61 (03) :113-116

← 1 2 3 4 5 →