ARE CHANGES IN EXPRESSION OF ACTIN GENES INVOLVED IN ESTROGEN-INDUCED CHOLESTASIS

被引：6
|
作者：
REYESROMERO, MA
机构：
来源：
MEDICAL HYPOTHESES | 1990年 / 32卷 / 01期
关键词：
D O I：
10.1016/0306-9877(90)90066-N
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
It is postulated that cholestasis associated with high estrogen levels found in women in various conditions, is due to alterations in structure and/or function of the system of actin microfilaments by estrogen-induced changes on expression of actin genes and/or some regulatory actin-binding protein genes. Because bile secretion by hepatocytes is apparently mediated by the microfilamentous system of actin, the proposed hormonally induced dysfunction of this system could be translated to cholestasis. © 1990.
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页码：39 / 43
页数：5
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