ANTIANAPHYLACTIC AGENTS .1. 2-(ACYLAMINO)OXAZOLES

被引：38

作者：

ROSS, WJ ^{[1
]}

HARRISON, RG ^{[1
]}

JOLLEY, MRJ ^{[1
]}

NEVILLE, MC ^{[1
]}

TODD, A ^{[1
]}

VERGE, JP ^{[1
]}

DAWSON, W ^{[1
]}

SWEATMAN, WJF ^{[1
]}

机构：

[1] LILLY RES CTR LTD,DEPT PHARMACOL,WINDLESHAM GU20 6PH,SURREY,ENGLAND

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1979年 / 22卷 / 04期

关键词：

D O I：

10.1021/jm00190a011

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and biological properties of 35 2-(acylamino)oxazoles are described. The majority of the compounds inhibit the release of slow-reacting substance of anaphylaxis (SRS-A) in vitro from sensitized guinea pig chopped lung. In addition, several of the compounds inhibited the release of SRS-A from passively sensitizedhuman chopped lung and protected guinea pigs from the effects of anaphylaxis in a modified Herxheimer test. © 1979, American Chemical Society. All rights reserved.

引用

页码：412 / 417

页数：6

共 18 条

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